1R1145 Sequence alignment method for homology modeling with high quality
نویسندگان
چکیده
منابع مشابه
Homology-extended sequence alignment
We present a profile-profile multiple alignment strategy that uses database searching to collect homologues for each sequence in a given set, in order to enrich their available evolutionary information for the alignment. For each of the alignment sequences, the putative homologous sequences that score above a pre-defined threshold are incorporated into a position-specific pre-alignment profile....
متن کاملMethod for predicting homology modeling accuracy from amino acid sequence alignment: the power function.
We have devised a power function (PF) that can predict the accuracy of a three-dimensional (3D) structure model of a protein using only amino acid sequence alignments. This Power Function (PF) consists of three parts; (1) the length of a model, (2) a homology identity percent value and (3) the agreement rate between PSI-PRED secondary structure prediction and the secondary structure judgment of...
متن کاملMolecular Homology and Sequence Alignment
Phylogenetic analysis depends crucially on the data underlying the analysis, with issues of data quality being but one aspect of the problem. A second, slightly less appreciated aspect is that of data comparability and specifically the evolutionary homology (= derivation from a common shared ancestry) of the individual characters being examined. The goal of sequence alignment is to establish th...
متن کاملDINAMO: a coupled sequence alignment editor/molecular graphics tool for interactive homology modeling of proteins.
Gaining functional information about a novel protein is a universal problem in biomedical research. With the explosive growth of the protein sequence and structural databases, it is becoming increasingly common for researchers to attempt to build a three-dimensional model of their protein of interest in order to gain information about its structure and interactions with other molecules. The two...
متن کاملSequence Matching in Homology Modeling
Homology-based modeling, or more simply homology modeling, is becoming increasingly important. Models accurate to within 1-2 Å RMS deviation from the actual three-dimensional structure can be produced by homology modeling in favorable cases. With the number of known threedimensional structures projected to grow to more than ten thousand structures by the end of the decade, it will be possible t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2002
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.42.s96_2